The history of the Laboratory dates back to 1980, when Prof. Władysław Torbicz introduced the subject of ion sensitive field-effect transistors (ISFET) to the IBBE PAS. Depending on the properties of the chemosensitive membrane material deposited on the transistor's gate, sensors sensitive to different ions can be obtained. The conducted research was focused on the development of:

• methods of chemical and enzymatic modification of ISFETs – ChemFET and EnFET, respectively,

• ion-sensitive membranes for K⁺, Na⁺, NH₄⁺, H⁺, Cl^-,

• enzymatic membranes with urease, creatinine kinase,

• sensor matrices based on p-well ISFETs for simultaneous measurements of multiple analytes.

Currently, research is being carried out on the developmenf of: voltammetric sensors made with the use of own direct printing technology, methods of biofunctionalization of (bio)chemically active surfaces and microanalytical systems such as P-o-C (Point-of-Care) for determination of different types of bioanalytes including biologically active substances.

2019

E. Remiszewska, K. Malecha, J. Kruk, J. Jankowska-Śliwińska, D. G. Pijanowska
Enzymatic method of urea determination in LTCC microfluidic system based on absorption photometry
Sensors and Actuators B: Chemical, 285, 2019, 375-384
DOI: 10.1016/j.snb.2019.01.032

2018

M. Urbanowicz, D. G. Pijanowska, A. Jasinski, M. Bochenska
Multianalyte Calibration Methods for Potentiometric Integrated Sensors System for Determination of Ions Concentration in a Body Fluids
2018 15th International Scientific Conference on Optoelectronic and Electronic Sensors, COE 2018
DOI: 10.1109/COE.2018.8435148

A. Paziewska-Nowak, T. Raczynski, D. G. Pijanowska, D. Janczak, M. Jakubowska
Evaluation of Fluorescein as a Label in Electrochemical and Optical Measurements
2018 15th International Scientific Conference on Optoelectronic and Electronic Sensors, COE 2018
DOI: 10.1109/COE.2018.8435165

E. Remiszewska, K. Dudzinski, J. Kruk, D. G. Pijanowska, K. Malecha
Mathematical Modeling of LTCC Based Microfluidic Type Chemical Microreactor
2018 15th International Scientific Conference on Optoelectronic and Electronic Sensors, COE 2018
DOI: 10.1109/COE.2018.8435168

A. Korzynska, Ł. Roszkowiak, K. Siemion, K. Pluta, D. G. Pijanowska
The analysis of the shape of the genetically modified human skin fibroblasts in culture
Advances in Intelligent Systems and Computing, 647, pp. 98-109
DOI:  10.1007/978-3-319-66905-2_8

2017

K. Dudzinski, M. Dawgul, K. Pluta, B. Wawro, W. Torbicz, D. G.Pijanowska
Spiral Concentric Two Electrode Sensor Fabricated by Direct Writing for Skin Impedance Measurements
IEEE Sensors Journal 17(16),7956148, pp. 5306-5314
DOI: 10.1109/JSEN.2017.2719001

A. Paziewska-Nowak, J. Jankowska-Śliwińska, M. Dawgul, D. G. Pijanowska
Selective Electrochemical Detection of Pirarubicin by Means of DNA-modified Graphite Biosensor
Electroanalysis 29(7), pp. 1810-1819
DOI: 10.1002/elan.201700067

J. Jankowska-Śliwińska, M. Dawgul, J. Kruk, D. G. Pijanowska
Comparison of electrochemical determination of purines and pyrimidines by means of carbon, graphite and gold paste electrodes
International Journal of Electrochemical Science 12(3), pp. 2329-2343
DOI: 10.20964/2017.03.16

Ł, Roszkowiak, A. Korzynska, J. Zak, D. G. Pijanowska, Z. Swiderska-Chadaj, T. Markiewicz
Survey: interpolation methods for whole slide image processing
Journal of Microscopy 265(2), pp. 148-158
DOI: 10.1111/jmi.12477

I. Osiecka, T. Pałko, W. Łukasik,  D. G. Pijanowska, K. Dudziński
Impedance spectroscopy as a method for the measurement of calibrated glucose solutions with concentration occurring in human blood
Advances in Intelligent Systems and Computing 519, pp. 211-216
DOI: 10.1007/978-3-319-46490-9_30

K. E. Zakrzewska, A. Samluk, A. Wencel, K. Dudek, D. G. Pijanowska, K. Pluta
Liver tissue fragments obtained from males are the most promising source of human hepatocytes for cell-based therapies - Flow cytometric analysis of albumin expression
PloS one 12(8), pp. e0182846
DOI: 10.1371/journal.pone.0182846

2016

C.-M. Yang, Y.H. Liao, C.-H. Chen, T.-C. Chen, C.-S. Lai, D. G. Pijanowska
P-I-N amorphous silicon for thin-film light-addressable potentiometric sensors
Sensors and Actuators, B: Chemical 236, pp. 1005-1010
DOI: 10.1016/j.snb.2016.04.092

A. Korzynska, J. Zak, L. Roszkowiak, D. G. Pijanowska, T. Markiewicz
Color standardization for the immunohistochemically stained tissue section images
IST 2016 - 2016 IEEE International Conference on Imaging Systems and Techniques, Proceedings 7738196, pp. 48-53
DOI: 10.1109/IST.2016.7738196

W.-Y. Chung, A. Silverio, V. F. Tsai, C. Cheng, S.-Y. Chang, Z. Ming-Ying, C.-Y. Kao, S.-Y. Chen, D. G. Pijanowska, D. Rustia, Y.-W. Lo
An implementation of an electronic tongue system based on a multi-sensor potentiometric readout circuit with embedded calibration and temperature compensation
Microelectronics Journal 57, pp. 1-12
DOI: 10.1109/ICSENS.2015.7370103

B. Kazimierczak, D. G. Pijanowska, A. Baraniecka, M. Dawgul, J. Kruk, W. Torbicz
Immunosensors for human cardiac troponins and CRP, in particular amperometric cTnI immunosensor
Biocybernetics and Biomedical Engineering 36(1), pp. 29-41
DOI: 10.1016/j.bbe.2015.11.008

T. Markiewicz, A. Korzynska, A. Kowalski, Z. Swiderska-Chadaj, P. Murawski, B. Grala, M. Lorent, M. Wdowiak, J. Zak, L. Roszkowiak, W. Kozlowski, D. G. Pijanowska
MIAP – Web-based platform for the computer analysis of microscopic images to support the pathological diagnosis
Biocybernetics and Biomedical Engineering 36(4), pp. 597-609
DOI: 10.1016/j.bbe.2016.06.006

2015

W.-Y. Chung, A.A. Silverio, V. F. Tsai, C. Cheng, S.-Y. Chang, Z. Ming-Ying, C.-Y. Kao, S.-Y. Chen, D. G. Pijanowska
An implementation of an electronic tongue system based on a multi-sensor potentiometric readout circuit with embedded calibration and temperature compensation
2015 IEEE SENSORS - Proceedings 7370103
DOI: 10.1109/ICSENS.2015.7370103

C. Ren, C.-M. Yang, C. Lyu, C.-Y. Hsu, T.-C. Chen, H.-C. Wang, H. Yang, W.-T. Lin, P.-C. Juan, C.-H. Huang, D. G. Pijanowska, J.-C. Wang, J.-R. Tsai
Nitrogen ratio and RTA optimization on sputtered TiN/SiO2 /Si electrolyte-insulator-semiconductor structure for pH sensing characteristics
Vacuum 118, pp. 113-117
DOI: 10.1016/j.vacuum.2015.02.025

1. W. Y. Chung, T. T. Kuo, Y. H. Wang, D. G. Pijanowska, W. Torbicz: Signal readout circuit for amperometric sensor, US Patent Pending, 2008.
2. W. Y. Chung, C. H. Yang, D. G. Pijanowska, P. Grabiec, B. Jaroszewicz, W. Torbicz: Electronic circuit for ion sensor with body effect reduction, US Patent, US 7,368,917 B2, 2008.
3. J. M. Łysko, D. G. Pijanowska: Semiconductor-type ion-selective sensor, Patent Pending PL347141, 2007.
4. J. M. Łysko, D. G. Pijanowska, E. Malinowska, J. Jaźwiński: Ion-selective silicon electrode, Polish Patent Pl193862, 2007.
5. W. Y Jung, A. Krzyśków, Y. T. Lin, D. G. Pijanowska, J. H. Yang: Ion-sensitive circuit, Taiwanese Patent, TW235236b, 2005.
6. W. Y. Chung, A. Krzyśków, Y. T. Lin, D. G. Pijanowska, C. H. Yang, W. Torbicz: Electronic circuit for ion sensor, US Patent US 6,906,524 B2, 2005.
7. A. Krzyśków, D. G. Pijanowska, J. Kruk: Controller of working point for chemical sensor of ion-sensitive field effect transistor ISFET type, Polish Patent Pl178242, 1996.