{"id":2623,"date":"2026-02-19T16:39:02","date_gmt":"2026-02-19T15:39:02","guid":{"rendered":"https:\/\/ibib.waw.pl\/?p=2623"},"modified":"2026-02-19T16:39:40","modified_gmt":"2026-02-19T15:39:40","slug":"projekt-preludium-bis-badanie-mechanizmu-oddzialywania-tiopuryn-z-dna-za-pomoca-nanostrukturyzowanych-bioplatform","status":"publish","type":"post","link":"https:\/\/ibib.waw.pl\/en\/projekt-preludium-bis-badanie-mechanizmu-oddzialywania-tiopuryn-z-dna-za-pomoca-nanostrukturyzowanych-bioplatform\/","title":{"rendered":"Prelude bis project \u201eInvestigating the mechanism of interaction of thiopurines with DNA using nanostructured bioplatforms\u201d."},"content":{"rendered":"<p>Terapia monitorowana st\u0119\u017ceniem leku we krwi\u00a0(ang.\u00a0<em>TDM \u2013 therapeutic drug monitoring<\/em>) jest to dopasowanie dawkowania leku tak, aby uzyskane st\u0119\u017cenie by\u0142o skuteczne, z jednoczesn\u0105 minimalizacj\u0105 dzia\u0142a\u0144 niepo\u017c\u0105danych lub efekt\u00f3w toksycznych. Przyk\u0142adem leku, dla kt\u00f3rego TDM ma kluczowe znaczenie jest azatiopryna \u2013 lek immunosupresyjny podawany po przeszczepieniach narz\u0105d\u00f3w i w terapii chor\u00f3b autoimmunologicznych (np. tocze\u0144, reumatoidalne zapalenie staw\u00f3w, choroba Le\u015bniowskiego-Crohna). Celem projektu jest opracowanie czujnika elektrochemicznego do oznaczania st\u0119\u017cenia azatiopryny i jej metabolit\u00f3w, kt\u00f3ry m\u00f3g\u0142by znale\u017a\u0107 zastosowanie w szybkiej i niskokosztowej\u00a0terapii monitorowanej st\u0119\u017ceniem leku.\u00a0<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"468\" src=\"https:\/\/ibib.waw.pl\/wp-content\/uploads\/2026\/02\/Badanie3-1024x468.png\" alt=\"\" class=\"wp-image-2601\"\/><\/figure>","protected":false},"excerpt":{"rendered":"<p>Terapia monitorowana st\u0119\u017ceniem leku we krwi\u00a0(ang.\u00a0TDM \u2013 therapeutic drug monitoring) jest to dopasowanie dawkowania leku tak, aby uzyskane st\u0119\u017cenie by\u0142o skuteczne, z jednoczesn\u0105 minimalizacj\u0105 dzia\u0142a\u0144 niepo\u017c\u0105danych lub efekt\u00f3w toksycznych. Przyk\u0142adem leku, dla kt\u00f3rego TDM ma kluczowe znaczenie jest azatiopryna \u2013 lek immunosupresyjny podawany po przeszczepieniach narz\u0105d\u00f3w i w terapii chor\u00f3b autoimmunologicznych (np. tocze\u0144, reumatoidalne zapalenie [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[47],"tags":[],"post_folder":[],"class_list":["post-2623","post","type-post","status-publish","format-standard","hentry","category-badania"],"acf":[],"_links":{"self":[{"href":"https:\/\/ibib.waw.pl\/en\/wp-json\/wp\/v2\/posts\/2623","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ibib.waw.pl\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/ibib.waw.pl\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/ibib.waw.pl\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/ibib.waw.pl\/en\/wp-json\/wp\/v2\/comments?post=2623"}],"version-history":[{"count":2,"href":"https:\/\/ibib.waw.pl\/en\/wp-json\/wp\/v2\/posts\/2623\/revisions"}],"predecessor-version":[{"id":2625,"href":"https:\/\/ibib.waw.pl\/en\/wp-json\/wp\/v2\/posts\/2623\/revisions\/2625"}],"wp:attachment":[{"href":"https:\/\/ibib.waw.pl\/en\/wp-json\/wp\/v2\/media?parent=2623"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/ibib.waw.pl\/en\/wp-json\/wp\/v2\/categories?post=2623"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ibib.waw.pl\/en\/wp-json\/wp\/v2\/tags?post=2623"},{"taxonomy":"post_folder","embeddable":true,"href":"https:\/\/ibib.waw.pl\/en\/wp-json\/wp\/v2\/post_folder?post=2623"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}