Enzyme Based Metal Organic Frameworks for Cancer Treatment<\/p>\n\n\n\n
BPN\/BFR\/2024\/1\/00025<\/strong><\/em><\/p>\n\n\n\n Project Manager: Dr. Kamila Sadowska, Prof. IBIB PAN<\/strong><\/p>\n\n\n\n Project funded by the National Agency for Academic Exchange (NAWA)<\/p>\n\n\n\n The project was submitted jointly with Abdelkader Zebda from Universit\u00e9 Grenoble Alpes within the competition for joint research projects between the Republic of Poland and the French Republic PHC Polonium 2024 NAWA - National Agency for Academic Exchange.<\/p>\n\n\n\n The aim of the project<\/strong>\u00a0is to develop enzyme-inorganic systems for effective anticancer therapy using a biocatalyst. Regulation of lactate levels in the tumor microenvironment may be a promising approach to control cancer cell proliferation and immune suppression to inhibit the growth of pathological tissue. Lactate oxidase, in the presence of oxygen, catalyzes the formation of pyruvate from lactate, with the release of hydrogen peroxide (H2<\/sub>O2<\/sub>), a compound with high cytotoxicity. After introducing lactate oxidase into the tumor environment, proliferation is inhibited due to a decrease in lactate concentration and cells are destroyed in reaction to the released hydrogen peroxide. Unfortunately, the need to administer high concentrations of the enzyme to maintain the required level of enzymatic activity under physiological conditions leads to the release of large amounts of H2<\/sub>O2<\/sub>, which also destroys healthy cells. In this project, we propose the development of enzyme-inorganic systems based on lactate oxidase with controlled composition and size (micro- and nanometric dimensions) to effectively target the tumor microenvironment and eliminate the problems associated with administering high doses of the enzyme in its native form.<\/p>","protected":false},"excerpt":{"rendered":" Enzyme Based Metal Organic Frameworks for Cancer Treatment BPN\/BFR\/2024\/1\/00025 Kierownik Projektu: dr hab. in\u017c. Kamila Sadowska, prof. IBIB PAN Projekt finansowany przez Narodow\u0105 Agencj\u0119 Wymiany Akademickiej (NAWA) Projekt z\u0142o\u017cono wsp\u00f3lnie z prof. Abdelkader Zebda z Universit\u00e9 Grenoble Alpes w ramach konkursu na wsp\u00f3lne projekty badawcze pomi\u0119dzy Rzeczpospolit\u0105 Polsk\u0105 a Republik\u0105 Francusk\u0105 PHC Polonium 2024 NAWA […]<\/p>\n","protected":false},"author":4,"featured_media":2419,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[13],"tags":[],"post_folder":[],"class_list":["post-2417","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-projekty"],"acf":[],"_links":{"self":[{"href":"https:\/\/ibib.waw.pl\/en\/wp-json\/wp\/v2\/posts\/2417","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ibib.waw.pl\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/ibib.waw.pl\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/ibib.waw.pl\/en\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/ibib.waw.pl\/en\/wp-json\/wp\/v2\/comments?post=2417"}],"version-history":[{"count":3,"href":"https:\/\/ibib.waw.pl\/en\/wp-json\/wp\/v2\/posts\/2417\/revisions"}],"predecessor-version":[{"id":2423,"href":"https:\/\/ibib.waw.pl\/en\/wp-json\/wp\/v2\/posts\/2417\/revisions\/2423"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/ibib.waw.pl\/en\/wp-json\/wp\/v2\/media\/2419"}],"wp:attachment":[{"href":"https:\/\/ibib.waw.pl\/en\/wp-json\/wp\/v2\/media?parent=2417"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/ibib.waw.pl\/en\/wp-json\/wp\/v2\/categories?post=2417"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ibib.waw.pl\/en\/wp-json\/wp\/v2\/tags?post=2417"},{"taxonomy":"post_folder","embeddable":true,"href":"https:\/\/ibib.waw.pl\/en\/wp-json\/wp\/v2\/post_folder?post=2417"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}