{"id":1185,"date":"2026-02-09T15:05:38","date_gmt":"2026-02-09T14:05:38","guid":{"rendered":"https:\/\/ibib.waw.pl\/?page_id=1185"},"modified":"2026-03-15T13:20:35","modified_gmt":"2026-03-15T12:20:35","slug":"zaklad-ii-pracownia-2","status":"publish","type":"page","link":"https:\/\/ibib.waw.pl\/en\/nauka\/zaklady-pracownie\/zaklad-ii-pracownia-2\/","title":{"rendered":"Laboratory of Nanohybrid Biosystems Regulation Engineering"},"content":{"rendered":"
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Head of Lab: Prof. Ludomira Granicka, PhD, DSc<\/strong>
Monika Drabik, PhD, Eng
Anna Grzeczkowicz, PhD
Angelika Kwiatkowska, PhD
Agata Lipko, PhD
Witold \u015arednicki, M.Sc.<\/p>\n<\/div>\n<\/div>\n<\/div><\/section>\n\n\n\n

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Topic: Nanobiosystems for biological processes regulation for therapeutic purposes<\/h2>\n\n\n\n

Research area: nanobiomaterial engineering, nanohybrid systems for the regulation of biological processes<\/strong>
The Laboratory uses and develops state-of-the-art nanobiomaterial engineering techniques in systems for regulating biological processes to support or replace tissue or organ function or anti-cancer effects.<\/p>\n\n\n\n

Work is carried out in the following aspects:<\/strong><\/p>\n\n\n\n

a) construction of targeted systems for delivering therapeutic or anti-cancer agents;
b) design of systems built of nanoelements with antimicrobial activity to cooperate with eukaryotic cells;
c) application of nanobiomaterials in systems for supporting the directed growth of eukaryotic cells.<\/p>\n\n\n\n


This involves, among others, the preparation and characterization of materials that demonstrate high application potential in terms of their later use in nanosystems intended, among others, for releasing a therapeutic agent. Within the characterization of biomaterials we standardized methods of biocompatibility assessment. \n In addition, work is carried out using the immobilization of biologically active material in membranes. Among the techniques we use, we should mention bioencapsulation, including nanoencapsulation, macroencapsulation and microencapsulation.
The research programs carried out in the Laboratory concerned, among others, effective nanocoating of biological material for immunoisolation purposes, including artificial pancreas, as well as analysis of the influence of factors produced by immobilized microorganisms on eukaryotic cells. Recently, work has been carried out on the construction of multilayer nanocomposite systems used to support the healing of difficult-to-heal wounds.   
The conducted research uses, among others: confocal microscopy, atomic force microscopy, spectroscopy, scanning electron microscopy, as well as flow cytometry and fluorescence microscopy. <\/p>\n\n\n\n

Keywords: <\/strong>bioencapsulation, immobilization, membrane, metallic nanoparticles, nanosystem, biocompatibility, anticancer therapy, antibacterial activity, antiviral activity, healing of difficult-to-heal wounds, nanobiomaterial. <\/p>\n\n\n\n

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Electron microscope view of micro-organisms (marked with a yellow circle) contained in a membrane structure intended for immunoisolation of micro-organisms (x5k)<\/em><\/p>\n<\/div>\n\n\n\n

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Electron microscope view of a nano-thin polyelectrolyte layer on a slide with adherent WEHI cells 164<\/em><\/p>\n<\/div>\n<\/div>\n\n\n\n

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Confocal microscope view of bacterial cells nanoencapsulated in a transferrin-incorporated coating with an attached fluorochrome-labelled antibody directed against transferrin.<\/em><\/p>\n<\/div>\n<\/div>\n<\/div><\/section>\n\n\n\n

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Honours and Awards:<\/h2>\n\n\n\n
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  • Monika Drabik, PhD: 2nd Maciej Na\u0142\u0119cz Award of the Director of the Institute of Biocybernetics and Biomedical Engineering of the Polish Academy of Sciences for a Young Researcher for scientific work in 2021 (presented on 30 September 2022).<\/li>\n\n\n\n
  • Dr Anna Grzeczkowicz: Award of the Director of the Maciej Na\u0142\u0119cz Institute of Biocybernetics and Biomedical Engineering of the Polish Academy of Sciences for a Young Employee<\/li>\n<\/ul>\n\n\n\n

    Selected publications from the JCR list from the last 10 years<\/h2>\n\n\n\n
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    1. Kwiatkowska A., Wierzchowski K., Lipko A., Grzeczkowicz A., Antosiak-Iwa\u0144ska M., Drabik M., Strawski M., Nowak B., Pilarek M., Granicka L.H.: Albumin-derived perfluorodecalin-based hybrid systems with developed effective surfaces aimed at biomedical application. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2024;694:134157. doi:10.1016\/j.colsurfa.2024.134157.<\/li>\n\n\n\n
    2. Mi\u0142ek, T.; Grzeczkowicz, A.; Lipko, A.; Mesjasz, M.; Oklesinski, L.; Kwiatkowska, A.; Strawski, M.; Drabik, M.; Granicka, L.H. An Oxygenated Layer Coating to Enhance the Healing Process of Non-Healing Wounds-A Case Report. Appl. Sci. 2024, 14, 11200. doi.org\/10.3390\/app142311200<\/li>\n\n\n\n
    3. Lipko, A.; Grzeczkowicz, A.; Antosiak-Iwa\u0144ska, M.; Strawski, M.; Drabik, M.; Kwiatkowska, A.; Godlewska, E.; Granicka, L.H.: Polyelectrolyte Platforms with Copper Nanoparticles as a Multifunctional System Aimed at Healing Process Support. Processes, 2024;12:512. doi: 10.3390\/pr12030512. <\/li>\n\n\n\n
    4. Kwiatkowska A., Granicka LH. Anti-Viral Surfaces in the Fight against the Spread of Coronaviruses. Membranes, 2023;13:464. doi: 10.3390\/membranes13050464.<\/li>\n\n\n\n
    5. Mi\u0142ek, T.; Grzeczkowicz, A.; Lipko, A.; Oleksinski, L.; Kwiatkowska, A.; Strawski, M.; Drabik, M.; Stachowiak, R.; Goliszewski, J.; Granicka, L.H. A Functionalized Membrane Layer as Part of a Dressing to Aid Wound Healing. Membranes, 2022;12:936. doi: 10.3390\/ membranes12100936.<\/li>\n\n\n\n
    6. Grzeczkowicz, A.; Lipko, A.; Kwiatkowska, A.; Strawski, M.; B\u0105cal, P.; Wi\u0119ckowska, A.; Granicka, L.H. Polyelectrolyte Membrane Nanocoatings Aimed at Personal Protective and Medical Equipment Surfaces to Reduce Coronavirus Spreading. Membranes, 2022;12:946. doi: 10.3390\/ membranes12100946.<\/li>\n\n\n\n
    7. A. Kwiatkowska, M. Drabik, A. Lipko, A. Grzeczkowicz, R. Stachowiak, A. Marszalik, L.H. Granicka. Composite Membrane Dressings System with Metallic Nanoparticles as an Antibacterial Factor in Wound Healing; Membranes (Basel), 2022;12(2):215 doi: 10.3390\/membranes12020215<\/li>\n\n\n\n
    8. A. Grzeczkowicz, A. Kwiatkowska, M. Drabik, L. Granicka: Nanoencapsulation of neuronal cells for cryopreservation purposes. Desalination and Water Treatment, 2021; 1-11; doi: 10.5004\/dwt.2021.26655.<\/li>\n\n\n\n
    9. M. Drabik, A. Grzeczkowicz, P. B\u0105cal, A. Kwiatkowska, M. Strawski, M. Antosiak-Iwa\u0144ska, B. Kazimierczak, Ewa Godlewska and Ludomira H. Granicka: Nanocomposite Membrane Scaffolds for Cell Function Maintaining for Biomedical Purposes. Nanomaterials, 2021, 11, 1094. https:\/\/doi.org\/10.3390\/nano11051094.<\/li>\n\n\n\n
    10. A. Grzeczkowicz, M. Drabik, A. Lipko, P. B\u0105cal, A. Kwiatkowska, Kazimierczak B., and L.H. Granicka: A Composite Membrane System with Gold Nanoparticles, Hydroxyapatite, and Fullerenol for Dual Interaction for Biomedical Purposes. Membranes, 2021; 11(8): 565. https:\/\/doi.org\/10.3390\/membranes11080565.<\/li>\n\n\n\n
    11. Drabik, M.; Grzeczkowicz, A.; B\u0105cal, P.; Kwiatkowska, A.;Strawski, M.; Antosiak-Iwa\u0144ska, M.;Kazimierczak, B.; Godlewska, E.;Granicka, L.H. Nanocomposite Membrane Scaffolds for Cell Function Maintaining for Biomedical Purposes. Nanomaterials, 2021; 11,1094. https:\/\/doi.org\/10.3390\/nano11051094<\/li>\n\n\n\n
    12. A. Grzeczkowicz, A. Kwiatkowska, M. Drabik, L. Granicka Nanoencapsulation of neuronal cells for cryopreservation purposes. Desalination and Water Treatment, 2021; 214:135-145<\/li>\n\n\n\n
    13. M. Antosiak-Iwa\u0144ska, P. B\u0105cal, B. Kazimierczak, A. Kwiatkowska, E. Godlewska, A. Grzeczkowicz, R. Stachowiak, J. Bielecki, L.H. Granicka. Polyelectrolyte Membrane with Hydroxyapatite and Silver Nanoparticles as a Material for Modern Wound Dressings. J Biomed Nanotechnol. 2020;16(5):702-714. doi: 10.1166\/jbn.2020.2907.<\/li>\n\n\n\n
    14. A. Trusek, E. Kijak, L. Granicka: Graphene oxide as a potential drug carrier - chemical carrier activation, drug attachment and its enzymatic release. Materials Science & Engineering C, 2020;116:111240; https:\/\/doi.org\/ 10.1016\/j.msec.2020.111240.<\/li>\n\n\n\n
    15. Dybowska-Sarapuk L., Weronika Sosnowicz, Jakub Krzeminski, Anna Grzeczkowicz, Ludomira H. Granicka, Andrzej Kotela and Malgorzata Jakubowska: Printed Graphene Layer as a Base for Cell Electrostimulation-Preliminary Results. Int. J. Mol. Sci., 2020; 21(21), 7865; doi:10.3390\/ijms21217865. <\/li>\n\n\n\n
    16. A. Grzeczkowicz, J. Gruszczy\u0144ska-Biegala, M. Czeredys, A. Kwiatkowska, M. Strawski, M. Szklarczyk, M. Ko\u017abia\u0142, J. Ku\u017anicki, L. H. Granicka: Polyelectrolyte membrane scaffold sustains growth of neuronal cells. J Biomed Mater Res Part A, 2019; 107(4):839-850. <\/li>\n\n\n\n
    17. A. Kwiatkowska, L. H. Granicka, A. Grzeczkowicz, R. Stachowiak, P. B\u0105cal, K. Sobczak, M. Darowski, M. Kozarski, J. Bielecki: Gold nanoparticle-modified poly(vinyl chloride) surface with improved antimicrobial properties for medical devices. J. Biomed. Nanotechnol. 2018;14: 922-932. <\/li>\n\n\n\n
    18. A. Kwiatkowska, L. H. Granicka, A. Grzeczkowicz, R. Stachowiak, M. Kami\u0144ski, Z. Grubek, J. Bielecki, M. Strawski, M. Szklarczyk: Stabilized nanosystem of nanocarriers with an immobilized biological factor for anti-tumor therapy. PlosOne, 2017; doi. 10.1371\/ journal.pone.0170925.<\/li>\n\n\n\n
    19. Marcin Strawski, Ludomira H. Granicka, Marek Szklarczyk: Redox properties of polyelectrolyte multilayer modified electrodes: a significant effect of the interactions between the polyelectrolyte layers in the films. Electrochimica Acta, 2017; 226: 121-131.<\/li>\n\n\n\n
    20. A. Kwiatkowska, L. Granicka, A. Grzeczkowicz, A. Chwojnowski, C. Wojciechowski, Nano-thin polyelectrolytes layers for biotechnological applications. Desalination and Water Treatment, 2017; 64: 260-265.<\/li>\n\n\n\n
    21. A. Grzeczkowicz, L. H. Granicka, I. Maciejewska, M. Strawski, M. Szklarczyk, M. Borkowska: The experimental study of the performance of nano-thin polyelectrolyte shell for dental pulp stem cell immobilization. J. Nanosci. Nanotechnol. 2015;15, 9531-9538.<\/li>\n\n\n\n
    22. Alicja Mackiewicz, Anna Grzeczkowicz, Ludomira Granicka, Magdalena Antosiak-Iwa\u0144ska, Ewa Godlewska, Dariusz Gozdowski, Dorota Olczak-Kowalczyk: Cytotoxicity of Nanocare Gold\u00ae material in In Vitro Assay - Pilot Study. Dent. Med. Probl. 2015; 52, 2, 167-174.<\/li>\n\n\n\n
    23. M. Borkowska, A. Grzeczkowicz, M. Strawski, J. Kawiak, M. Szklarczyk, L. H. Granicka: Performance and detection of nano-thin polyelectrolyte shell for cell coating. J Nanopart Res, 2014; 16 (7): art. no. 2488.<\/li>\n\n\n\n
    24. Ludomira H. Granicka: Nanoencapsulation of Cells Within Multilayer Shells for Biomedical Applications. J Nanosci Nanotechnol, 2014;14, 705-716.<\/li>\n\n\n\n
    25. L. H. Granicka, M. Borkowska, A. Grzeczkowicz, R. Stachowiak, M. Szklarczyk, J. Bielecki, M. Strawski: The targeting of nanothin polyelectrolyte shells in system with immobilized bacterial cells for antitumor factor production. J Biomed Mater Res A, 2014; 102 (8): 2662-2668.<\/li>\n<\/ol>\n\n\n\n

      Selected patents<\/h2>\n\n\n\n
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      1. L. Granicka, A. Grzeczkowicz, A. Kwiatkowska: Membrane system for local targeted immobilisation of cells and method of its manufacture, Patent RP No. 236035; 2020.<\/li>\n\n\n\n
      2. L. Granicka, M. Borkowska, A. Grzeczkowicz, Rados\u0142aw Stachowiak, Jacek Bielecki: Polyelectrolyte membrane for the isolation of microorganisms, Gram (-) and Gram (+), and a method of its production. Polish Patent No. 226841; 2017.<\/li>\n\n\n\n
      3. L. Granicka, A. Grzeczkowicz, M. Borkowska: Membrane system for local immobilisation of cells and method of its manufacture. Polish Patent No. 225257; 2017.    <\/li>\n<\/ol>\n<\/div><\/section>","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":0,"parent":918,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"page-subpage.php","meta":{"_acf_changed":false,"_only_polish":false,"footnotes":""},"folder":[29],"class_list":["post-1185","page","type-page","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/ibib.waw.pl\/en\/wp-json\/wp\/v2\/pages\/1185","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ibib.waw.pl\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/ibib.waw.pl\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/ibib.waw.pl\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/ibib.waw.pl\/en\/wp-json\/wp\/v2\/comments?post=1185"}],"version-history":[{"count":12,"href":"https:\/\/ibib.waw.pl\/en\/wp-json\/wp\/v2\/pages\/1185\/revisions"}],"predecessor-version":[{"id":3033,"href":"https:\/\/ibib.waw.pl\/en\/wp-json\/wp\/v2\/pages\/1185\/revisions\/3033"}],"up":[{"embeddable":true,"href":"https:\/\/ibib.waw.pl\/en\/wp-json\/wp\/v2\/pages\/918"}],"wp:attachment":[{"href":"https:\/\/ibib.waw.pl\/en\/wp-json\/wp\/v2\/media?parent=1185"}],"wp:term":[{"taxonomy":"folder","embeddable":true,"href":"https:\/\/ibib.waw.pl\/en\/wp-json\/wp\/v2\/folder?post=1185"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}