154th ICB SEMINAR

Eleventh International Seminar

on

STATISTICS AND CLINICAL

PRACTICE

May 11 - 13, 2017, Warsaw, Poland

Organised by
INTERNATIONAL CENTRE OF BIOCYBERNETICS

Seminar goals

The ICB Seminars "Statistics and Clinical Practice" held in Warsaw since 1994, have become a tradition as a meeting space for statisticians from various countries, dealing with problems related to medicine. Both scientific and didactic goals define a part of the Conference framework. The Seminar provides an opportunity for professional discussions among biostatisticians, while medical doctors are offered an opportunity to discuss statistical problems with leading experts in the field.

The following topics will be addressed during the Seminar:

• prognostic models selection
• exploratory analysis of big biomedical data sets
• data mining methods in bioinformatics
• meta analysis of biomedical data sets
• new models in survival analysis
• clinical epidemiology
• scan statistics
• study designs for individualized medicine

Program and Organising Committee

Leon Bobrowski
Institute of Biocybernetics and Biomedical Engineering PAS, Warsaw, Poland

Cornelia Enachescu
Institute of Mathematical Statistics and Applied Mathematics, Bucharest, Romania

Cristian Preda
Ecole Polytechnique Universitaire de Lille 2, France

A special session adressed to medical doctors will be organized under the title:

Statistical standards in medical research projects and publications

Chair: Dr Ewa Kawalec

The session is organized by the Polish National Group of the International Society for Clinical Biostatistics (ISCB)

PROGRAMME OF THE SEMINAR

Thursday, May 11

OPENING OF THE SEMINAR
10.00 – 10.15
WELCOME ADDRESS by Piotr Ładyżyński (Poland)
Director of the International Center of Biocybernetics

Chair: Cornelia Enăchescu

10.15 – 11.00 Alain Duhamel, Cristian Preda (France)
“Meta –analysis in practice: a tutorial”

11.00 – 11.30 Barbara Kowalczyk, Wojciech Niemiro, Robert Wieczorkowski (Poland)
“Estimation of sensitive features via item count technique with a continuous variable”

11.30 – 12.00 Evgeniya Babykina (France)
“Survival analysis applied to disease transmission modelling”

12.00 – 12.30 Vlad Stefan Barbu, Nikolaos Limnios (France)
“Survival analysis for Markov and semi-Markov models and application to breast cancer data”

12.30 – 13.00 Laurentiu Vasile (Romania)
“Common problems in the interlaboratory comparison schemes”

13.00 – 14.00 LUNCH BREAK

Chair: Cristian Preda

14.00 – 14.30 Cornelia Enachescu, Denis Enachescu (Romania)
“Sample size determination and power analysis for clinical research”

14.30 – 15.00 Vincent Vandewalle (France)
“Dealing with missing data through mixture models”

15.00 – 15.30 Florence Loingeville, Thu Thuy Nguyen, Marie-Karelle Rivière, France Mentré (France)
“Using hamiltonian Monte-Carlo to design longitudinal count studies accounting for parameter and model uncertainties”

GET TOGETHER PARTY FOR LECTURERS
AND ACCOMPANYING PERSONS
17:00 – 18:00

Friday, May 12

Chair: Jeremy Clark

10.15 – 11.00 Attila Gyenesei, Witold Bauer (Austria, Poland)
“Hierarchical biclustering and its application in biomedical research”

11.00 – 11.30 Jeremy Clark, Anna Sałacka, Agnieszka Bińczak-Kuleta, Thierry van de Wetering, Jarosław Sławek, Monika Białecka, Mateusz Kurzawski, Krzysztof Safranow, Andrzej Ciechanowicz, Torsten Hothorn (Poland, Switzerland)
“Power studies for medical data analysed by Kruskal-Wallis”

11.30 – 12.00 Małgorzata Ćwiklińska-Jurkowska, Anna Wolińska-Welcz (Poland)
“Grade multivariate approach for selection of genes discriminating prediction of cancer recurrence in comparison with other methods”

13.00 – 14.00 LUNCH BREAK

Chair: Attila Gyenesei

14.00 – 14.30 Leon Bobrowski (Poland)
“Basics of collinear biclustering”

14.30 – 15.00 Alexandru Amarioarei (Romania)
“Extension of the classical discrete scan statistics framework with applications”

15.00 – 15.30 Tomasz Byrski, Cezary Cybulski, Tadeusz Dębniak, Bohdan Górski, Józef Kładny, Grzegorz Kurzawski, Jan Lubiński, Aaneta Mirecka, Steven A. Narod, Katarzyna Paszkowska-Szczur, Rodnej J. Scott, Pablo Serrano-Fernandez, Thierry van de Wetering (Poland, Canada, Australia)
“Review of common variants in the XPD gene related to cancer risk”

POSTER SESSION
15.30 – 17.00

Chair: Denis Enachescu

Małgorzata Cwiklińska – Jurkowska, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, (Poland)
“Exploration of relationships between genes selection and classification by single and combined methods”

Dorota Jankowska, Anna J. Milewska, Dorota Citko, Robert Milewski, Department of Statistics and Medical Informatics, Medical University of Bialystok, (Poland)
“Decision trees as a support of prediction of infertility treatment outcomes”

Tomasz Łukaszuk1, Leon Bobrowski1,2, 1Faculty of Computer Science, Bialystok University of Technology, (Poland), 2Institute of Biocybernetics and Biomedical Engineering, PAS, (Poland)
“The Relaxed Linear Separability method in high-dimensional data analysis”

Paweł Zabielski1, Leon Bobrowski1,2, 1Faculty of Computer Science, Bialystok University of Technology, Bialystok, (Poland), 2Institute of Biocybernetics and Biomedical Engineering, PAS, Warsaw, (Poland)
“Computer implementation of biclustering procedures”

Saturday, May 13

STATISTICAL STANDARDS IN MEDICAL RESEARCH PROJECTS AND PUBLICATIONS

The special session addressed to medical doctors
organized by the Polish National Group
of the International society for Clinical Biostatistics (ISCB)

Chair: Ewa Kawalec

9.30 – 10.00 Małgorzata Ćwiklińska-Jurkowska, Collegium Medicum, Bydgoszcz, Nicolaus Copernicus University, (Poland) “Application of multivariate statistics in development of personalized medicine”

10.00 – 10.30 Katarzyna Szamotulska, Institute of Mother and Child (Poland)
“Clinician-statistician communication in medical research”

10.30 – 11.00 COFFEE BREAK

11.00 – 11.30 Krystyna Szafraniec, Institute of Public Health, Faculty of Health Sciences, Jagiellonian University Medical College, (Poland)
“Setting up a multivariable analysis. Predictors, confounders and effect modifiers”

11.30 – 12.00 Ryszard Mężyk, Holy Cross Cancer Center, (Poland)
“The projects and websites in epidemiology of cancer”

12.00 – 12.20 Maciej Polak, Institute of Public Health, Faculty of Health Sciences, Jagiellonian University Medical College (Poland)
“Power and simple size calculation, whether 80 cases is enough?”

12.20 – 12.30 Closing of the Seminar

GENERAL INFORMATION

Seminar format

The Seminar will include lectures by distinguished biostatisticians and information technology specialists from various countries. Beside these lecturers there will be also a poster session. There is a possibility of contributing to the session in a different way, agreed by an applicant researcher with the organizers. Part of the sessions will be didactic in character and will be addressed particularly to medical researchers.
Time and location
The Seminar will take place in Poland, Warsaw, at 4 Trojdena Str., on May 11 - 13, 2017.
The seminar venue will be in the buildings of Nałęcz Institute of Biocybernetics and Biomedical Engineering (IBIB) of the Polish Academy of Sciences and the International Centre of Biocybernetics. The Institute is located in the new research centre comprising several institutes and hospitals (Ochota Campus). It can be reached conveniently by a 10-minute car drive from the airport and it is close to the central railway station.
Accommodation
Participants can be accommodated in Warsaw hotels (costs of accommodation are not covered by the organisers).

The Preliminary Programme will be distributed around April 15, 2017.
Contributions
An extended abstract in English of the length up to 6 pages, clearly stating the purpose of the poster presentation, results and conclusions should be submitted to the Seminar Secretariat (see the full address details at the end of the announcement). The title and name(s) of the author(s), affiliations, postal and e-mail addresses should be included.
Received abstracts will be reviewed. The accepted abstracts will be published in the seminar proceedings and research results will be presented at the conference during the poster session. Instructions for authors can be found on the web page:
http://ibib.waw.pl/images/ibib/grupy/MCB/Dokumenty/TEMPLATE.rtf

A special issue of the Lecture Notes of the ICB Seminars "Statistics and Clinical Practice" will be devoted to the accepted papers from the Seminar.

Scientific Secretary

Dr Małgorzata Krętowska
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Dr Magdalena Topczewska
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All correspondence including extended abstracts should be sent to:
Mrs. Barbara Wolff
Seminar Statistics and Clinical Practice
International Centre of Biocybernetics
ul. Ks. Trojdena 4, 02-109 Warsaw, Poland
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Tel. (+48 22) 592-59-70
Fax. (+48 22) 592-59-98

Seminar fee

The registration fee is 100 PLN. You will be issued with an invoice after we receive your payment.
There is also a possibility to apply for a fee reduction. Please contact Mrs. Barbara Wolff
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Bank details for payment:

Bank name: Bank Gospodarstwa Krajowego
SWIFT code: GOSKPLPW
IBAN PL 30 1130 1017 0020 1447 0820 0001

Receiver of the payment:

INSTYTUT BIOCYBERNETYKI I INZYNIERII BIOMEDYCZNEJ PAN
Księcia Trojdena Str., 02-109 Warszawa
VAT EU: PL5250009453
Please indicate "Statistics and Clinical Practice Seminar" and your name in transfer description. You will cover bank costs of the course fee transfer.

Eleventh International Seminar on
STATISTICS AND CLINICAL PRACTICE
May 11 - 13, 2017, Warsaw, Poland